Interestingly, our results also confirmed previous studies, implying that dysregulated levels of HMGB1 as potent target of miR-1247-5p have exerted modulatory effects on neuroinflammation markers, NLRP3, IL-1β, IL-18, and IL-6, reinforcing their potential roles in mitigating pyroptosis and neuroinflammation in PD. Here, NLRP3 is linked to Parkinson disease.