Recent studies have demonstrated that excessive Mn exposure to neuronal cells has lowered the expressions of miR-675-5p by sponging with lncSh2d3c, resulting in the neuronal apoptosis through lncSh2d3c/mmu-miR-675–5p/Chmp4b/Bax axis and aggravated neurodegenerative processes [31] However, in glioma studies, overexpressed miR-675-5p has promoted glioma cell proliferation migration and invasion by downregulating various tumour suppressor genes, such as retinoblastoma 1(RB1) [32]. This evidence concerns the gene RB1 and central nervous system cancer.