In a randomly selected subset of the study population (70 patients and 54 controls), serum pyroptosis-associated protein HMGB1 (P = 0.0429, Fig. 5A) and IL-18 (P = 0.0199, Fig. 5C) were significantly increased in PD patient’s serum compared to control. The gene discussed is HMGB1; the disease is Parkinson disease.