The significant downregulation of miR-361 and miR-4500 expression in extracapsular nodal spread (ECS) and acute lymphoblastic leukemia (ALL) cell lines leads to inhibition of their binding to the target gene STAT3, thereby enhancing STAT3 expression and ultimately accelerating the occurrence and development of ECS and ALL [107–109]. Here, STAT3 is linked to acute lymphoblastic leukemia.