At the same time, STAT3 upregulates the expression of lncRNAs by binding to their promoters, forming lncRNA/IL-6/STAT3 or lncRNA/IL-11/STAT3 loops, which enhance the drug resistance of tumor cells [68, 97], or promoting tumor growth and metastasis in vivo and inhibiting tumor cell apoptosis [69, 70]. The gene discussed is IL11; the disease is neoplasm.