Studies have shown that lncRNAs, such as H19, HOST2, SNHG16, MIAT, NEAT1, GACAT3, and SNHG1, serve as molecular sponges for miRNA, which can downregulate miRNA levels and inhibit their binding to STAT3 to enhance STAT3 expression, thereby accelerating the progression of cancers such as BC [60, 61], HCC [62–64], gastric cancer (GC) [65], renal cell carcinoma (RCC) [66], and CRC [67, 84], by inducing tumor cell proliferation, migration, and invasion. This evidence concerns the gene STAT3 and hepatocellular carcinoma.