STAT3 and neoplasm: Studies have shown that lncRNAs, such as LOC645166 and TRPM2-AS, can upregulate the expression of STAT3 by regulating downstream genes or proteins other than miRNAs and ILs, such as GATA binding protein 3 (GATA3) and p38 mitogen-activated protein kinase, ultimately promoting tumor cell proliferation, migration, and invasion, or enhancing tumor tissue chemotherapy resistance [98–102].