STAT3 and neoplasm: On the one hand, lncRNAs such as FAL1, FEZF1-AS1, PVT1, and RP11-334E6.12 can upregulate STAT3 expression by binding to the STAT3 promoter and inducing STAT3 phosphorylation, thereby directly inducing tumor cell proliferation and inhibiting apoptosis [52–58, 83].