miRNAs (e.g., miR-19a and miR-18a) can downregulate components of the STAT3 signaling pathway, such as suppressor of cytokine signaling 3 (SOCS3), SOCS5, and protein inhibitor of activated STAT3 (PIAS3), in tumor cells, thereby activating STAT3, and ultimately promoting tumor cell migration, invasion, and EMT [111–113]. Here, PIAS3 is linked to neoplasm.