ICAM1 and asthma: For example, ABO A blood group has been found to increase the risk of early childhood asthma and Streptococcus pneumoniae infection43; affect the serum level of ICAM-1, a cell-surface glycoprotein typically expressed on endothelial cells and immune cells44; and increase the risk of coronary artery disease45 and affect circulating levels of cardiovascular-disease-related proteins46.