Two decades later, Drosophila cells carrying ‘neoplastic tumour-suppressor’ genes such as scribble (scrib), discs large (dlg), lethal giant larvae (lgl), rab5, vps25, Tumor susceptibility gene 101 (TSG101), and avalanche, were identified as “losers” when juxtaposed with wild-type cells; of note, in isolation these cells displayed over-proliferation [10–19]. This evidence concerns the gene TSG101 and neoplasm.