Astrocytes play a significant role in glutamate uptake by clearing 80 ~ 90% of synaptic glutamate in the synaptic cleft;61–65 glutamate uptake transporters, excitatory amino acid transporters 1 (EAAT1) and 2 (EAAT2) (known in mouse as Slc1a3 solute carrier family 1 (glial high-affinity glutamate transporter), member 3 (Slc1a3) (also known as GLAST) and solute carrier family 1 (glial high-affinity glutamate transporter), member 2 (Slc1a2) (also known as GLT-1), respectively) were expressed in astrocytes of AD patients66–69. Here, SLC1A2 is linked to Alzheimer disease.