In the brains of model AD mice, A1 reactive astrocytes had upregulated expression of genes including histocompatibility 2, T region locus 23 (H2-T23), serpin family G member 1 (Serping1), histocompatibility 2, D region locus 1 (H2-D1), glycoprotein alpha-galactosyltransferase 1 (Ggta1), interferon inducible GTPase 1 (Iigp1), guanylate binding protein 2 (Gbp2), fibulin 5 (Fbln5), UDP glucuronosyltransferase family one member A1 (Ugt1a1), FK506 binding protein 5 (Fkbp5), proteasome 20 S subunit beta 8 (Psmb8), serglycin (Srgn), and adhesion molecule with Ig like domain 2 (Amigo2). The gene discussed is GBP2; the disease is Alzheimer disease.