IREB2 and Alzheimer disease: The expression of ferroptosis-related genes, such as iron response element binding protein 2 (Ireb2), citrate synthase (Cs), ribosomal protein L8 (Rpl8), and prostaglandin-endoperoxide synthase 2 (Ptgs2), was upregulated in hippocampal tissues of APP/PS1 AD model mice39.