A total of 136 nonsilent NSMs were identified in normal samples, with an average of 4.9, and 81 NSMs were identified in BPHs, with an average of 6.3, in the trio cases (p = 0.042), including the COSMIC cancer genes FOXA1, KMT2C, and BCOR (Supplementary Table 7). This evidence concerns the gene KMT2C and cancer.