ADAMTS4 and arthritic joint disease: Furthermore, we observed a significant decrease in the osteoarthritic chondrocyte phenotype in the flag-WTAP chondrocytes after DAA treatment, including decreased mRNA levels of arthritis-related genes (ADAMTS4, ADAMTS5, MMP13, IL-6, IL-8, iNOS) and decreased protein levels of ADAMTS4, ADAMTS5, and MMP13 (Fig. 6e–g).