Rossato et al.42 reported that TLR-2 deficiency resulted in impaired phagocytosis and the impaired production of cytokines, such as TNF-α, IL-6, and IL-10, during Sporothrix brasiliensis infection, and that a lack of TLR-2 also resulted in an increased dissemination of S. brasiliensis and a polarized Th-17 response to control infection. This evidence concerns the gene TNF and infection.