KRAS and bladder transitional cell carcinoma: Hallmark pathways including the KRAS signaling pathway69, epithelial-mesenchymal transition70, DNA repair71, glycolysis72, signaling73, and a few other pathways-related genes were then screened through the prognostic genes and 71 hallmark pathway genes were found to be differentially methylated from the process which was involved in the survival of the cancer patients and used for NMF clustering of the BLCA patients by exploiting the expression data of these 71 genes.