SLC35A3 and colorectal carcinoma: In CRC cases, a missense mutation Y117F was detected in the Nuc_sug_transp domain, and the three-dimensional structure of the SLC35A3 protein showed the Y117F mutation in Fig. 5C. Other mutations, including V44A, M82T, Y113N, R207S, and E229, were detected in the SLC35A3 protein structure in other CRC patients.