The results showed that low expression of SLC35A3 mRNA was significantly associated with N stage (p = 0.004), pathological stage (p = 0.041), and lymph node invasion (p < 0.001), while it had no significant correlation with T stage, M stage, sex, age, CEA level, residual tumor, and neural invasion (p > 0.05). Here, SLC35A3 is linked to neoplasm.