For example, fusion proteins are hallmarks of many human cancers produced by chromosomal translocations during neoplastic transformation, accounting for a variety of uncontrolled malignant cellular processes.43 Indeed, we used our STIF-based design framework and created a sensor for BCR-ABL, a representative cytosolic biomarker of CML44 (Supplementary information, Fig. S9a). This evidence concerns the gene ABL1 and cancer.