Finally, using another xenograft model based on Hepa1-6EGFP-NS3a(H1)-derived tumors, we demonstrated PAFP-driven EGFP-NS3a(H1)-dependent activation of apoptosis in vivo (Fig. 6d–f), with self-sufficient tumor lysis correlating again with effective Bax expression (Supplementary information, Fig. S10d). This evidence concerns the gene BAX and neoplasm.