To test such a distinction logic in vitro, we first transiently transfected expression vectors for MCP-LaG16, (ANR)8-NSP3 and PAFP-driven reporter mRNA into neuronal Neuro-2A (N2A) and murine hepatoma-derived Hepa1-6 cells engineered for stable EGFP-NS3a(H1) expression. Here, SH2D3C is linked to hepatocellular carcinoma.