The expression of CD11a was significantly higher on intermediate monocytes from normal weight OSAS patients (p = 0.0423) as well as in the obesity cohort (p = 0.0028), and also on non-classical monocytes from both patient cohorts (p = 0.0056; p =  < 0.0001) as compared to healthy donors (Fig. 2A). This evidence concerns the gene ITGAL and obesity due to melanocortin 4 receptor deficiency.