To further explicitly distinguish the specific impact of OSAS and obesity on systemic immunological balances, we analyzed plasma levels of adiponectin, leptin, lipocalin and metalloproteinase 9 (MMP-9) from normal weight OSAS patients and patients with obesity without OSAS using ELISA measurements. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.