ITGB4 and central nervous system cancer: Tissue microarray analysis showed that overall survival (HR = 3.37, 95% CI 2.21–5.14, p =  < 0.001, Fig. 4B) in glioma and in LGG (HR = 6.02 95%CI 3.28–11.04), P < 0.001, Fig. 4C) was significantly poorer in cases with high ITGB4 expression.