However, ITGB4 does not predict GBM prognosis (OS: LGG, HR = 1.352, 95% CI 1.190–1.535, p =  < 0.001; GBM: HR = 1.135, 95% CI 0.986–1.307, p = 0.074; PFI: LGG, HR = 1.401,95% CI 1.224–1.603, p =  < 0.001; GBM: HR = 1.119, 95% CI 0.961–1.304, p = 0.148; DSS: LGG, HR = 1.275, 95% CI 1.148–1.416, p =  < 0.001; GBM: HR = 1.096, 95% CI 0.946–1.270, p = 0.222). The gene discussed is ITGB4; the disease is glioblastoma.