Prenatal Δ9-THC has been linked to increased glucose intolerance among female offspring only [60••], which may be attributable to sex-specific differences in the development of the endocannabinoid system [119] (which plays a key role in metabolism [84] and glucose homeostasis [85]) or insulin resistance (which tends to be higher in prepubertal girls as compared to prepubertal boys [120]). This evidence concerns the gene INS and Glucose intolerance.