They are in line with our study, with activation of the NLRP3 inflammasome, FXR expression was reduced in LX2 cells and in the liver of mice with CCl4-induced and GCDCA-induced hepatic fibrosis compared to the control mice (Figs. 2a, c, 3e, 6f). This evidence concerns the gene NLRP3 and Hepatic fibrosis.