Downstream of Gata3, signaling products Il5 and Il13 showed enhanced expression in the ta-ILC2s–with and without IL33/TSLP stimulation relative to naïve, unstimulated ILC2s–which suggests that ILC2s may respond to distant neoplasm in a similar way as other viral and parasitic infections, and release type 2 cytokines. Here, TSLP is linked to parasitic infectious disease.