Thus, we exposed skin-expanded Vδ1+ cells either to agonists for the TCR, namely plate-bound anti-TCR-Vδ1 or anti-CD3, or to agonists for the activating cytotoxic NKR, NKG2D (encoded by KLRK1), namely recombinant MHC class I polypeptide-related sequence A (MICA), a stress-associated ligand upregulated in many cancers (Extended Data Fig. 5a). This evidence concerns the gene MICA and cancer.