Hence, whereas these cancers are de facto concealed from CD8+ T cells, they may be visible to γδ T cells, possibly explaining the fact that intratumoral γδ T cells, particularly tissue-associated Vδ1+ cells, have consistently been linked to favorable clinical outcomes, for example, improved survival, in many cancer settings often independent of colocated αβ T cells10,11,22–24. The gene discussed is CD8A; the disease is cancer.