GRN and acute myeloid leukemia: TF binding motifs enriched in both sets of t(6;9) specific footprints as compared to those of healthy PBSCs (Supplementary Fig. 1E) included occupied EGR, NF1 and AP-1 motifs, confirming that these core nodes of the GRN are involved in regulating t(6;9)-specific AML gene expression.