Unsupervised clustering of this data together with previously generated DNaseI-seq data from patients with other genotypes [2, 9], showed that t(6;9) AML is part of the larger FLT3-ITD, NPM1 and FLT3-ITD/NPM1 AML cluster (Fig. 1A). This evidence concerns the gene FLT3 and acute myeloid leukemia.