Moreover, mRNA expression of HOXA7, HOXA9, HOXA11 (in both patient samples but not FKH1 cells) and HOXB2 genes were significantly lower in t(6;9) AML compared to FLT3-ITD and NPM1 AML (Fig. 2C, Supplementary Table 1), although still upregulated and more accessible than in, for example, t(8;21) AML. This evidence concerns the gene FLT3 and acute myeloid leukemia.