NPM1 and acute myeloid leukemia: This analysis showed that t(6;9) AML shares key regulatory TF nodes with FLT3-ITD and NPM1 AML such as NFIL3, FOXC1, NFIX, WT1, EGR1 and AP-1 (FOSL2), which are essential for FLT3-ITD/NPM1 AML maintenance [2, 10] and which were also de-regulated in t(6;9) AML (Fig. 1B, Supplementary Fig. 1C).