NPM1 and acute myeloid leukemia: MLL-Menin modulates upregulation of HOX genes in NPM1-mutated and SET::NUP214 AML [5, 12], whilst other NUP fusion proteins cause upregulation of HOX genes [3] through co-operation of NUP proteins with XPO1 (CRM1) [13] enriched at HOX promoters [14].