NPM1 and acute myeloid leukemia: However, the majority of differentially expressed genes with HOX/MEIS motifs, including lymphoid genes, MEIS1 and AP-1 family member genes, were expressed at least 2-fold higher in NPM1 patients (Supplementary Fig. 2C, Supplementary Table 1) suggesting reduced reliance on HOX factors in t(6;9) AML.