Clustering just t(6;9), FLT3-ITD and NPM1 DHS data (Supplementary Fig. 1D) and plotting the average signal across NPM1 or FLT3-ITD specific DHSs (Fig. 1C, right), showed that t(6;9) patient chromatin was accessible at the NPM1- but not the FLT3-ITD-AML specific sites. This evidence concerns the gene NPM1 and acute myeloid leukemia.