AKT1 and colorectal cancer: Bishnupuri et al.48 reported that when Akt was specifically blocked, the addition of canuridine did not affect the rates of apoptosis and proliferation in human colorectal cancer cells, suggesting that canuridine may enhance the activity of β-catenin via the PI3K/Akt signaling pathway, thereby affecting proliferation and apoptosis in human colorectal cancer cells.