In our study, we analyzed plasma samples obtained from n = 19 pDoC patients and n = 12 HCs, evaluating a broader interval of 1–18 months after brain injury, observing a higher value of BDNF in pDoC patients (mean = 16,696 pg/ml) compared to HCs (mean = 4254 pg/ml). The gene discussed is BDNF; the disease is brain injury.