We also observed that Col18a1, which encodes the alpha chain of type XVIII collagen implicated in ureteric tree development46 and which we previously reported in AKI29, is elevated in the fibrotic kidney TECs, while it’s receptor encoding genes (Gpc1/4, Itga5/b1) are expressed in Fibro 1, 2 and 3 clusters, highlighting a putative interaction pathway present in both AKI and CKD models. This evidence concerns the gene GPC1 and chronic kidney disease.