At the same time, the relationship of CKMT2 mRNA expression in different pathological stages of various cancer types was evaluated, and it was found that the expression of CKMT2 in IV stage of BLCA, HNSC, LUAD, and THCA was lower than that in stage I. On the contrary, the expression of CKMT2 in stage IV was higher than that in stage I in KIRP (Supplementary Figure S1A-E). The gene discussed is CKMT2; the disease is bladder transitional cell carcinoma.