ATP10A and obesity due to melanocortin 4 receptor deficiency: Prior studies analyzing mice with an overlapping series of radiation-induced deletions encompassing the p locus on chromosome 7 implicated Atp10A deficiency in diet-induced obesity, insulin resistance indicated by reduced efficacy of insulin in mediating glucose disposal, and hyperlipidemia, and reported that these phenotypes were more severe in females compared to males26,27.