Indeed, the percentage of immature blast cells in the PB (Fig. 7b), leukemia cell infiltration in the spleen (Fig. 7c), the spleen weight (Fig. 7d) and the percentage of Ki-67+ cells in the spleen (Fig. 7e) were substantially increased after rmCXCL16 treatment in mice with secondary BCR-ABLtTA B-ALL cell transplantation. This evidence concerns the gene MKI67 and acute lymphoblastic leukemia.