TNF and precursor B-cell acute lymphoblastic leukemia: Similar to the findings in mouse primary B-ALL cells treated with IL-17A, the hallmark inflammatory response, hallmark IL6/JAK/STAT3 signaling and hallmark TNF signaling via NF-kB pathways were significantly enriched (FDR q < 0.25) in the IL-17RA high subgroup (Fig. 4c and Supplementary Fig. 4e).