Gene set enrichment analysis (GSEA) showed that genes involved in the hallmark IL6/JAK/STAT3 signaling, hallmark TNF signaling via NF-kB, and hallmark inflammatory response pathways were highly enriched in primary mouse Ph+ B-ALL cells treated with IL-17A (Fig. 4b and Supplementary Fig. 4a, b). This evidence concerns the gene NFKB1 and precursor B-cell acute lymphoblastic leukemia.