CXCL16 and leukemia: To determine whether CXCL16 secreted by leukemia cells promotes the migration of Th17 cells, which in turn maintains the survival of leukemia cells, we separately isolated Th17 cells and leukemia cells from Ph+ B-ALL patients and then cocultured the leukemia cells with the Th17 cells in a noncontact coculture system (Fig. 5i).