Meanwhile, compared to VSV-NP K65R infection, the expression of Ifnb1, Isg56, and Cxcl10 in macrophages maintained in vitro (Supplementary Fig. 7o) or mice organs (spleen, liver, and lungs; Fig. 7h, Supplementary Fig. 7p), as well as the concentration of IFN-β in the mice sera (Fig. 7i), decreased accordingly to significant lower levels after VSV-NP K65R-R203K/R203K infection. This evidence concerns the gene CXCL10 and infection.