Decreased accessibilities were found within CAP1 (SCN), CAP2 (DMN+) and CAP7 (DMN−-ATN−) in MDD patients, while CAP3 (SCN−-CN−), CAP5 (pooled network) and CAP6 (ATN+) exhibited increased accessibility in MDD patients (Fig. 3C). Here, TYR is linked to major depressive disorder.