CASP8 and major depressive disorder: As shown in Supplementary Table S4, dwell time of CAP3 (SCN−-CN−) (r = 0.1715, P = 0.0107) yields strong positive relationship with depression severity, while dwell time of CAP4 (SCN+) (r = −0.1882, P = 0.0050) is negatively correlated with depression severity.