CASP8 and major depressive disorder: As shown in Fig. 3B, Pearson correlation reveals a significant correlation between depression severity and transition probabilities from CAP1 (SCN) to CAP3 (SCN−-CN−) (r = 0.1924, P = 0.0041), CAP1 (SCN) to CAP6 (ATN+) (r = −0.17, P = 0.0114), CAP4 (SCN+) to CAP2 (DMN+) (r = 0.1381, P = 0.0403), CAP5 (pooled network) to CAP6 (ATN+) (r = 0.1458, P = 0.0303), CAP7 (DMN−-ATN−) to CAP4 (SCN+) (r = −0.2789, P < 0.0001).