In current study, we identified seven CAPs encompassing CAP1 (SCN), CAP2 (DMN+), CAP3 (SCN−-CN−), CAP4 (SCN+), CAP5 (pooled network), CAP6 (ATN+), and CAP7 (DMN−-ATN−) in the MDD cohort. This evidence concerns the gene CASP8 and major depressive disorder.