Overall, MDD patients showed a significantly reduced dwell time in CAP1 (SCN), CAP2 (DMN+), and CAP7 (DMN−-ATN−), and a significantly increased dwell time in CAP3 (SCN−-CN−), CAP5 (pooled network) and CAP6 (ATN+) (Fig. 2A). Here, TYR is linked to major depressive disorder.