Decreased entropy of Markov trajectories from CAP1 (SCN) to CAP3 (SCN−-CN−) (r = −0.1929, P = 0.004), within CAP3 (SCN−-CN−) (r = −0.1596 P = 0.0176), CAP7 (DMN−-ATN−) to CAP3 (SCN−-CN−) (r = −0.1475, P = 0.0284) were associated with elevated depression severity. The gene discussed is CAP1; the disease is depressive symptom measurement.