Enhanced entropy of Markov trajectories from CAP2 (DMN+) to CAP4 (SCN+) (r = 0.1725, P = 0.0102), CAP3 (SCN−-CN−) to CAP4 (SCN+) (r = 0.1465, P = 0.0295), within CAP4 (SCN+) (r = 0.1588, P = 0.0182), CAP6 (ATN+) to CAP4 (SCN+) (r = 0.2008, P = 0.0027) and CAP7 (DMN−-ATN−) to CAP4 (SCN+) (r = 0.2472, P = 0.0002) were correlated with increased depression severity (Fig. 3D). The gene discussed is SRI; the disease is major depressive disorder.