The decreased dwell time of CAP1 (SCN) in MDD patients was consistently observed in 5 of the 6 sites except site 1 due to data imbalance (nMDD = 31, nhealthy controls = 6), followed by CAP5 (pooled network) and CAP6 (ATN+) (4 of the 6 sites), CAP7 (DMN−-ATN−) and CAP3 (SCN−-CN−) (3 of the 6 sites). This evidence concerns the gene CAP1 and major depressive disorder.