Brain surface renderings of baseline tau-PET SUVR and longitudinal tau-PET change rates are shown in Fig. 1, illustrating elevated cross-sectional temporoparietal tau-PET SUVRs and longitudinal tau-PET increase in 54 Aβ+ patients on the AD spectrum patients vs. absent tau accumulation in the 39 CN Aβ− controls. This evidence concerns the gene MAPT and Alzheimer disease.