Ablation of Adrenomedullin/CALCRL signaling impedes the activation of ERK signaling, leading to the formation of abnormal jugular lymphatic vessels.63 Blockade of Adrenomedullin/CALCRL signaling after normal lymphatic vessel formation resulted in impaired permeability and function in intestinal, corneal, and dermal lymphatic vessels.352 In several types of cancers, Adrenomedullin significantly increased tumor-associated lymphangiogenesis.353,354. This evidence concerns the gene CALCRL and neoplasm.