Acute GVHD is triggered by alloreactive T cells that damage peripheral tissues and lymphoid organs.295 Gehlsen et al. found that lymphangiogenesis is involved in the pathogenesis of ocular GVHD.296 In addition, Mertlitz et al. found that acute GVHD was associated with lymphangiogenesis in murine allo-HSCT models and in intestinal tissue biopsy samples taken from patients, while the administration of anti-VEGFR3 antibodies suppressing lymphangiogenesis ameliorated GVHD and prolonged the survival in murine models.297. Here, FLT4 is linked to graft versus host disease.