VEGFC and neoplasm: Qingjie Fuzheng Granule and Pien Tze Huang exhibit inhibitory effects on tumor growth and lymphangiogenesis via the PI3K/AKT/VEGFC pathway.195,196 In addition, an ethanol extract of Hedyotis diffusa Willd suppresses VEGFC-stimulated LEC migration and tube formation while concurrently downregulating the expression of downstream molecules involved in the VEGFC/VEGFR3 signaling pathway, such as MMP2, MMP9, cyclin D1, and CDK4.197