WNT5B and cancer: Among the WNT family members, WNT5A and WNT5B have been reported to exert a positive effect on lymphangiogenesis.344,345 WNT5A regulates dermal lymphangiogenesis mainly through the noncanonical β-catenin-independent signaling pathway.346 Cancer cell-derived WNT5B modulated lymphangiogenesis and lymphatic permeability through the activation of both canonical and noncanonical WNT signaling pathways.344