VEGFC and pancreatic neoplasm: Under hypoxic conditions, BANCR is overexpressed in pancreatic cancer and promotes lymphangiogenesis by upregulating the HIF-1α/VEGFC/VEGFR3 pathway.175 In contrast, circular RNA (circRNA) circNFIB1 exerts a suppressive effect on lymphangiogenesis by downregulating the effect of miR-486-5p and upregulating PIK3R1 expression to inhibit VEGFC signaling.176 VEGFC could be secreted from cells in extracellular vesicles to facilitate lymphangiogenesis.