Thus, VEGFC enhances lymphangiogenesis and cancer cell invasion into lymphatic vessels through paracrine and autocrine mechanisms, ultimately leading to lymph node metastasis.177 Additionally, based on the aforementioned mechanism, Wang et al. reported a selective inhibitor B390 of HDAC1/2 that effectively suppressed lymphangiogenesis by reinstating DUSP2 expression.178 Other studies have been aimed at understanding lymphangiogenesis independent of VEGFC action. The gene discussed is VEGFC; the disease is cancer.