Yang et al. demonstrated that the elevation of oxLDL levels in plasma induced the activation of the nuclear factor (NF)-κB pathway through binding with LOX-1, leading to the upregulation of VEGFC expression and subsequently facilitating lymphangiogenesis.185 The rate-limiting enzyme SOAT1 in the cholesterol metabolic pathway exerts effect by upregulating the SREBP1 and SREBP2 expression.186 Furthermore, recent studies have also reported several factors that impede lymphangiogenesis in gastric cancer. This evidence concerns the gene VEGFC and gastric cancer.