LDLR and infection: Indeed, pre-incubation of SINV-EEEV with LDLR-Fc or LBD-Fc did not block infection of LDLR-expressing THP-1 cells (Fig. 4a) or N2a ΔB4galt7 cells (Supplementary Fig 4a) even at relatively high (10 μg/ml) concentrations, whereas they did block infection by VSV, an unrelated rhabdovirus that can use LDLR as an entry receptor39,40.