Whereas infection with SINV-WEEV, SINV-SFV, and GETV was decreased in N2a ΔB4galt7 ΔLdlr cells, SINV, SINV-CHIKV, MAYV, and SINV-VEEV did not show significantly reduced infection in N2a ΔB4galt7 ΔLdlr cells compared to N2a ΔB4galt7 cells (Fig. 1b, c, Supplementary 1h), suggesting that for some alphaviruses, LDLR is not required for infectivity in these cells, possibly due to expression of alternate entry factors. This evidence concerns the gene LDLR and infection.