TNF and central nervous system cancer: Utilizing GSEA, we discovered that the up-regulated target genes were primarily associated with classical carcinogenesis pathways and immune response pathways, such as the p53, IL 17, TNF, NF-kappa B, PI3K-Akt, NOD-like receptor and TOLL-like receptor signaling pathways, suggesting that m6A modification increases glioma proliferation and immune response (Figure 2G).