Direct examination of the mRNA‐encoding adipogenesis markers AdipoQ, PPARg, and FABP4 in the RNA‐seq data also showed no difference in U9‐KO compared with WT (Figure 4d–f), altogether suggesting that U90926 deficiency in vivo has minimal effects on obesity‐related gene expression in pWAT. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.