INS and obesity due to melanocortin 4 receptor deficiency: On the contrary, we have not found any major effect of U90926 deficiency in vivo in terms of weight gain and other obesity‐related phenotypes, such as fat accumulation, metabolic changes including plasma levels of glucose, TG, NEFA, and insulin, WAT histology, and adipogenesis molecular markers (Figures 2, 3, 4).