MYC is a critical transcription factorwhose aberrant activityis implicated in more than 75% of all human cancer cases.1−3 Numerous studies have established that MYC can facilitate cancerinitiation, maintenance, and progression by boosting transcriptionactivities.2,4−6 Although its exact mechanismof action is under debate,7−11 MYC has long been one of the most sought-after oncology drug targets.12−14 Despite decades of research, MYC remains an “undruggable”target with no clinically viable therapeutics.5,12. The gene discussed is MYC; the disease is cancer.