The team's immunohistochemical studies indicated that JADE1 may be involved in 4R and mixed 3R/4R tauopathies; they observed immunopositivity not only in PART tangles, but also in tangles of tauopathies with aggregates that contained 4R tau and in mixed tauopathies with aggregates that contained both 3R and 4R tau. The gene discussed is MAPT; the disease is tauopathy.