Human brain tissue from patients with AD26, 30, 32 and frontotemporal dementia (FTD) due to the MAPT IVS10+16 mutation31 features invaginations of the nuclear envelope that harbor disease‐associated phosphotau, in line with electron microscopy‐based analyses in 2006 that reported “nuclear contour irregularity” in AD.33 This evidence concerns the gene MAPT and frontotemporal dementia.