While most of the earliest tau research took place within the context of AD, for example, presentations at Tau 2022 underscored tau's role in a wide range of disorders, ranging from classic tauopathies such as PSP and CBD to an expanding list of conditions not classically categorized as tauopathies, such as Parkinson's disease, Down syndrome, autism, and epilepsy. The gene discussed is MAPT; the disease is Down syndrome.