The authors further concluded that it is unlikely that exon 10 splicing alone underlies and regulates disease pathogenesis and tau neuropathology in either AD or PSP; instead, it is likely that the combined expression of specific N‐ and C‐terminal MAPT isoforms plays a role in the development of each tauopathy. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.