Although sequential tau distribution patterns have been recognized for tau pathologies such as Pick's disease, argyrophilic grain disease, and astrocytic tau pathologies, as well as for other proteinopathies,76 the development of a scoring or staging system that incorporated sequential distribution patterns in PSP presented a challenge because of the range of its tau cytopathologies and clinical phenotypes. The gene discussed is MAPT; the disease is proteostasis deficiencies.