A proportionally higher frequency of rare variants derived from the ancestral populations has been reported in a study of the genomes from 900 Colombian individuals with AD, frontotemporal lobar degeneration (FTLD)‐motor neuron disease, early‐onset dementia not otherwise specified, and healthy participants, with 21 pathogenic variants in AD‐FTLD‐related genes and PSEN1 representing the majority.58 This evidence concerns the gene PSEN1 and Alzheimer disease.