MAPT and epilepsy: Although the mechanisms by which such dysfunctions are ameliorated are unknown, tau reduction may alter neurons in ways that reduce the occurrence of epilepsy‐promoting processes such as excitation/inhibition (E/I) imbalance, hyperexcitability, and hypersynchronization, which are believed to contribute to cognitive impairments and behavioral alterations in a range of disease models.108, 109, 110