Yang et al. (2022) also observed that AKT overexpression in p38/ERK/AKT/NF-kB signaling could inhibit anti-intestinal epithelial cell (IEC) apoptosis during giardiasis mediated by COX-2-mediated and ROS/NO production (Yang et al. 2022). This evidence concerns the gene PTGS2 and giardiasis.