We identified 166 and 423 genes upregulated in C9orf72-ALS OPCs and oligodendrocytes, respectively, with 225 and 201 genes downregulated compared to their respective controls (Supplementary Fig. 5a, d) (FC > 1.2, FDR < 0.05). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.