When we analyzed the snRNAseq data of OPCs/oligodendroglia from the motor cortex of patients with C9orf72 mutant ALS, among 8 and 16 lipid-related DEGs (Fig. 5l), 3 and 7 lipid metabolism genes that can be regulated by FUS, respectively, were found deregulated (Fig. 5m). Here, C9orf72 is linked to amyotrophic lateral sclerosis.