Thus, there is a possibility that FUS may be involved in the deregulated abnormal lipid metabolism in oligodendroglia, even if it is difficult to state this unequivocally, as deregulation of lipid metabolism genes was also observed in the motor cortex of a subpopulation of patients with sporadic ALS and in OPCs and oligodendrocytes of patients with C9orf72-mutant ALS. Here, C9orf72 is linked to amyotrophic lateral sclerosis.