Within tumor-infiltrating CD8+ T cells, the glucocorticoid receptor was shown to be highly expressed in exhausted CD8+ T cells and to promote the upregulation of genes associated with T cell dysfunction.31 A recent study showed that HSD11B1-generated glucocorticoids by tumor cells promote resistance to immunotherapy through the stimulation of Treg function32. Here, HSD11B1 is linked to neoplasm.