Similarly, CSC expressing high levels of CD44 were found to significantly elevate TNF-α secretion along with other inflammatory cytokines such as Interleukins (IL-1beta, IL-10, IL-12) and angiogenic factors (Angiopoietin-1 & 2, VEGF, and bFGF) owing to increased oral tumor stemness (121). The gene discussed is CD44; the disease is neoplasm.