The discrepancy in Gal-3 KO mice between reperfused and non-reperfused MI can be partially explained by the role of fibrosis and the scar in each model; while the scar is transmural in non-reperfused large MI and needs to provide adequate tension, a patchy and subendocardial scar is observed in reperfused MI (Lindsey et al., 2021). This evidence concerns the gene LGALS3 and myocardial infarction.