MYC and neoplasm: Through GSVA (Supplementary Figures S13A, B) and GSEA (Supplementary Figures S13C, D), we observed a significant activation of tumor-associated biological processes such as EMT, cell proliferation (MYC targets, E2F targets, G2M checkpoints, and cell cycle), and signaling pathways like WNT/β-catenin and PI3K/AKT/MTOR pathways in the high PCDI score group.