In response to such phenomenon, the researchers further revealed Nucleophosmin 3 (NPM3) transferred by EVs derived from brown adipose tissue regulate the stability of PR domain-containing 16 (PRDM16) mRNA and enhance the expression of browning-related genes, indicating EVs from adipose tissue might represent a promising therapeutic strategy for metabolic diseases [20]. This evidence concerns the gene PRDM16 and metabolic disease.