At the same time, researches on white adipose tissue EVs revealed that obese visceral adipose tissue EVs exhibited proteins associated with adipose tissue inflammation and insulin resistance, such as transforming growth factor-β1 (TGF-β1), Cav1, CD14, mimecan, thrombospondin-1, fatty acid binding protein 4 (FABP-4), and AHNAK nucleoprotein (AHNAK). This evidence concerns the gene AHNAK and Insulin resistance.