At the same time, researches on white adipose tissue EVs revealed that obese visceral adipose tissue EVs exhibited proteins associated with adipose tissue inflammation and insulin resistance, such as transforming growth factor-β1 (TGF-β1), Cav1, CD14, mimecan, thrombospondin-1, fatty acid binding protein 4 (FABP-4), and AHNAK nucleoprotein (AHNAK). Here, FABP4 is linked to Insulin resistance.