INS and metabolic disease: Meanwhile, clinical studies have shown that the levels of miR-7-5p, miR-20a-5p, miR-92a-3p, miR-195-5p, and miR-374b-5p in adipocyte-derived EVs were significantly downregulated after the treatment of T2DM with pioglitazone, in contrast to miR-195-5p, whose changes in miRNA expression were associated with lipolytic inhibition and improvement of insulin sensitivity were closely correlated [98], revealing the potential of adipocyte EVs and related contents as diagnostic targets for metabolic diseases.