APOE and Alzheimer disease: Genetic changes in AD pathology include mutations in genes (Chai, 2007; Lambert and Amouyel, 2007) including APP Presenilin-1, Presenilin-2 (Bertram and Tanzi, 2012; Van Giau et al., 2019), Apolipoprotein E(Yamagata et al., 2001) and Neuronal sortilin-related receptor (Li et al., 2007; Rogaeva et al., 2007; Vasudevaraju et al., 2008).