TBXT and Alzheimer disease: The "amyloid cascade hypothesis," which has dominated the AD field for the past 20 years, has served as the foundation for most of these pharmacological drugs' design and/or development.According to this idea, the primary cause of AD is the metabolism of the Aβ-peptide which, along with the subsequent accumulation of τ-protein aggregates, causes neuronal, synaptic dysfunction, loss of microglial activation and neuronal death.