Elevated expression of serine hydroxymethyltransferase 2 (SHMT2) correlates with poor OS and relapse-free survival (RFS), the amino acid transporter ASCT2 (SLC1A5) correlates with poor RFS (80), endoplasmin (HSP90B1) has been associated with distant metastasis and worse OS, and decorin (DCN) has been associated with lymph node metastasis, increased number of positive lymph nodes and worse OS; and (81). This evidence concerns the gene HSP90B1 and metastatic malignant neoplasm in the lymph nodes.