Bone metastases of breast cancer are characterized by increased expression of the TFF1, TFF3, AGR2, NAT1 and CR1P1 genes, as well as the chemokine receptors CXCR4 and C-C chemokine receptor type 7 (CCR7), and upregulation of the zinc finger protein SNAI1 (SNAI1) (45, 109), which is involved in the induction of EMT (110). Here, CCR7 is linked to breast carcinoma.