5’ UTR polymorphisms of the DEFB1 gene (rs11362, rs1800972, and rs1799946) were studied to check if they had any association with susceptibility to periodontitis and also periodontitis with T2DM conditions. DNA isolated from saliva was amplified for the DEFB1 gene, and the representative gel image of amplification is shown in Figure 1. The gene discussed is DEFB1; the disease is type 2 diabetes mellitus.