Notably, mTOR and GPX4 exhibit interactions: (a) mTORC1 inhibition sensitizes cancer cells or tumors to ferroptosis and acts synergistically with ferroptosis inducers to inhibit tumor growth 121, (b) mTORC1 inhibition reduces GPX4 levels 121, 122 and (c) RSL3 blocks mTOR activation 121, 123. The gene discussed is MTOR; the disease is cancer.