A recent study indicated that lithium chloride ameliorates ischemic brain injury and alleviates associated cognitive impairment by inhibiting nucleotide-binding oligomerization domain, leucine-rich repeat and nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome activation through AKT/GSK-3β/β-catenin and AKT/forkhead box O3 (FoxO3a)/β-catenin pathways 12. Here, FOXO3 is linked to Cognitive impairment.