EBF1 and B-cell non-Hodgkin lymphoma: We focused on LMP1 and EBNA2, because of their importance for B cell immortalization in culture (16) and because of the following three observations from our previous work: (i) Transgenic expression of LMP1 in mice causes spontaneous monoclonal B cell lymphomas (31); (ii) some of these B cell lymphomas had acquired mutations in Ebf1 as a secondary oncogenic event (32); and (iii) co-expression of LMP1 and cellular EBF1 is able to recapitulate EBV-mediated transformation in mice, and to promote survival and proliferation of human tonsillar B cells in culture (32).