For example, overexpression of VSIG4 in high-grade gliomas (24), gastric cancer (25), and multiple myeloma (26) have been associated with poor prognosis, while low VSIG4 expression in tumor tissue was related to poor prognosis in patients with HBV-associated hepatocellular carcinoma (27). This evidence concerns the gene VSIG4 and hepatocellular carcinoma.