Firstly, while our bioinformatics analysis has indeed revealed a positive correlation between the expression of the four genes (PLEKHO2, VSIG4, MPP1, and GBP2) and the infiltration of CD8+ T cells in osteosarcoma, the precise mechanism by which these genes foster CD8+ T cell infiltration remains elusive. This evidence concerns the gene PLEKHO2 and osteosarcoma.