MiR-126 is under-expressed in NSCLC cells, and overexpression of miR-126 inactivates PI3K/Akt signaling by targeting vascular endothelial growth factor A (VEGFA) and multidrug resistance-related protein 1 (MRP1) pathway and induced a significant reduction in the maximal inhibitory concentrations of adriamycin (ADM) and vincristine (108). The gene discussed is PIK3CB; the disease is non-small cell lung carcinoma.