Previous studies have shown that the expression of miR-25-3p is up-regulated in cisplatin-resistant NSCLC cells, and enhance cisplatin resistance by regulating PTEN/PI3K/AKT signaling pathway, and inhibition of miR-25-3p may become a new strategy to overcome cisplatin resistance in NSCLC (42). This evidence concerns the gene PIK3CD and non-small cell lung carcinoma.