Interestingly, miR-374a was shown to play a dual role in NSCLC, miR-374a exerted a protective effect by inactivating PI3K/AKT and RAS-mediated cell cycle signaling, as well as epithelial-mesenchymal transition (EMT) through direct targeting of CCND1 in the early stage of NSCLC. This evidence concerns the gene PIK3CD and non-small cell lung carcinoma.