PIK3CA and lung carcinoma: In contrast, miR-379-5p expression was found to be significantly down-regulated in lung cancer, and elevated levels of miR-379-5p would result in reduced levels of phosphorylated PI3K and p-AKT, in addition to inhibit the growth of cells and promote cell death via direct targeting of ARRB1, a scaffolding protein that mediates the desensitization and internalization of G protein-coupled receptors (GPCR) (64).