For instance, it was discovered that overexpression of the miR-449a gene would down-regulate nicotinamide n-methyltransferase (NNMT), a tumor-metabolizing enzyme, and cause an increase in the expression of PTEN, which would inhibit tumor growth, in EGRR-AKT resistant NSCLC cells. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.