Similarly, it was found that overexpression of miR-29a could block the IL-13-induced invasive process in A549 cells by inactivating the PI3K/AKT/AKT/YY1 axis (98).MiR-4458 expression was observed to be decreased in NSCLC cells, and miR-4458 increased levels inactivated the PI3K/AKT signaling pathway, limiting NSCLC migration and EMT progression (66). This evidence concerns the gene PIK3CA and non-small cell lung carcinoma.