PIK3CA and neoplasm: For example, miR-126 expression was markedly downregulated in NSCLC,miR-126 overexpression, which targets PIK3R2 and deactivates the PI3K-Akt signaling pathway, inhibits LUAD cell proliferation as well as tumor growth rate and size in xenograft tumor models (47) (87)ADDIN.By obstructing the PI3K/Akt pathway, miR-1 reduces the tumorigenicity of NSCLC cells in a xenograft tumor model (48).