AGT and hypertensive disorder: The present model, therefore, differs from prior models that used intravenous ANG II infusion by the absence of direct effects of ANG II on the vasculature (vasocontraction and subsequent hypertension), as well as the heart itself (hypertrophy), or metabolic abnormalities, and as such, it is likely to provide information that is not available from the other models, yet it is complementary to the already available models.