Moreover, the overexpression of death-associated protein kinase (DAPK), and its inactivation mediated by the hypermethylation of DAPK promoter region result in the accumulation of genomically-damaged epithelial cells in the inflamed colonic epithelium in UC patients, which may initiate the development of UC-related carcinoma (Kuester et al., 2010). This evidence concerns the gene DAPK1 and carcinoma.