KAT2B knockdown inhibited the occupancy of KAT2B and thereby H4K5 acetylation (H4K5ac) at IL-10 promoter regions, resulting in the transcriptional silencing of the anti-inflammatory cytokine IL-10 in the inflamed IBD tissues (Bai et al., 2016). This evidence concerns the gene KAT2B and irritable bowel syndrome.