ZBTB7B and colitis: DNA hypo-methylation of gene Zbtb7b, referred to as the Th-inducing POZ-Kruppel factor (Th-POK), could activate the maturation of CD4+ T cells and repress the differentiation of double-positive T cells, leading to the secretion of inflammatory cytokines and thus causing colonic inflammation in UC (Xu et al., 2022a).