EDN1 and spontaneous coronary artery dissection: The genes associated with the risk for SCAD were the F11R (the gene responsible for F11 receptor which is a regulator of tight junction assembly), TLN1 ( the gene encoding Talin 1 which is responsible for linking the actin cytoskeleton to the extracellular matrix), TSR1 (the gene which influences ribosome maturation factor and RNA formation), already mentioned PHACTR1 (the gene important for cytoskeleton actine), and EDN1 (encoding endothelin 1 which is a circulating vasoactive peptide) (17).